購(gòu)物車(chē)
幫助
021-54845833/15800441009
中文名稱(chēng)： CYFIP2抗原（重組蛋白）
英文名稱(chēng)： CYFIP2 Antigen (Recombinant Protein)
別 名： PIR121
儲(chǔ) 存： 冷凍（-20℃）
相關(guān)類(lèi)別： 抗原
概 述：
|
Fusion protein corresponding to a region derived from C terminal 250 amino acids of human CYFIP2 |
|
Full name: |
cytoplasmic FMR1 interacting protein 2 |
|
Synonyms: |
PIR121 |
|
Swissprot: |
Q96F07 |
|
Gene Accession: |
BC011762 |
|
Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
|
Expression system: |
Escherichia coli |
|
Tags: |
His tag C-Terminus, GST tag N-Terminus |
|
Background: |
CYFIP2 (Cytoplasmic FMR1-interacting protein 2, p53-inducible protein 121) is a 1,278 amino acid protein encoded by the human gene CYFIP2. CYFIP2 belongs to the CYFIP family and is involved in T-cell adhesion and p53-dependent induction of apoptosis. It interacts with FMR1, FXR1 and FXR2 and is a component of the WAVE1 complex composed of Abi-2, CYFIP2, C3orf10/HSPC300, NAP125 and WASF1/WAVE1. Upon binding to activated Rac 1, CYFIP2 causes the complex to dissociate, releasing activated WASF1. The CYFIP2 promoter contains a p53-responsive element that confers p53 binding as well as transcriptional activation of a heterologous reporter. Induced expression of CYFIP2 is sufficient for caspase activation and cellular apoptosis, reminiscent of p53 activation. |
