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  • BRSK1抗原(重組蛋白)

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    • 品牌 : 通蔚生物
    • 目錄號 : TW16340
    • 應(yīng)用 : 僅限于科研使用
    • 貨期 : 現(xiàn)貨
    • 規(guī)格 :1mg/100ug
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中文名稱: BRSK1抗原(重組蛋白)

英文名稱: BRSK1 Antigen (Recombinant Protein)

別       名: BR serine/threonine kinase 1; hSAD1

相關(guān)類別: 抗原

儲(chǔ)       存: 冷凍(-20℃)

概述

Fusion protein corresponding to a region derived from 579-778 amino acids of human BRSK1

技術(shù)規(guī)格

Full name:

BR serine/threonine kinase 1

Synonyms:

hSAD1

Swissprot:

Q8TDC3

Gene Accession:

BC016681

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

The phosphorylation and dephosphorylation of proteins on serine and threonine residues is an essential means of regulating a broad range of cellular functions in eukaryotes, including cell division, homeostasis and apoptosis. A group of proteins that are intimately involved in this process are the serine/threonine (Ser/Thr) protein kinases. BRSK1 (BR serine/threonine-protein kinase 1), also known as SAD1, is a 794 amino acid protein that localizes to both the nucleus and the cytoplasm and contains one UBA domain and one protein kinase domain. Expressed in a variety of tissues with highest expression in testis and brain, BRSK1 uses magensium as a cofactor to catalyze the ATP-dependent phosphorylation of target proteins, including Wee 1 and Cdc25B. Via its kinase activity toward proteins that are involved in microtubule assembly, BRSK1 plays an essential role in neuronal polarization and may be involved in regulating cell cycle arrest in response to DNA damage, Two isoforms of BRSK1 exist due to alternative splicing events.

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