Name: MITF抗原（重組蛋白）
Brand: 通蔚生物

中文名稱(chēng)： MITF抗原（重組蛋白）

英文名稱(chēng)： MITF Antigen (Recombinant Protein)

別名： MI; WS2; CMM8; WS2A; COMMAD; bHLHe32

儲(chǔ) 存： 冷凍（-20℃）

相關(guān)類(lèi)別： 抗原

概述

Fusion protein corresponding to a region derived from 354-526 amino acids of human MITF

技術(shù)規(guī)格

Full name:	melanogenesis associated transcription factor
Synonyms:	MI; WS2; CMM8; WS2A; COMMAD; bHLHe32
Swissprot:	O75030
Gene Accession:	BC026961
Purity:	>85%, as determined by Coomassie blue stained SDS-PAGE
Expression system:	Escherichia coli
Tags:	His tag C-Terminus, GST tag N-Terminus
Background:	This gene encodes a transcription factor that contains both basic helix-loop-helix and leucine zipper structural features. It regulates the differentiation and development of melanocytes retinal pigment epithelium and is also responsible for pigment cell-specific transcription of the melanogenesis enzyme genes. Heterozygous mutations in the this gene cause auditory-pigmentary syndromes, such as Waardenburg syndrome type 2 and Tietz syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified.

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