購物車
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021-54845833/15800441009
中文名稱：ALPL抗原（重組蛋白）
英文名稱：ALPL Antigen (Recombinant Protein)
儲 存：冷凍（-20℃）
相關(guān)類別：抗原
概述
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Fusion protein corresponding to a region derived from 1-329 amino acids of human ALPL |
技術(shù)規(guī)格
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Full name: |
alkaline phosphatase, biomineralization associated |
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Synonyms: |
HOPS; TNAP; TNALP; APTNAP; TNSALP; AP-TNAP |
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Swissprot: |
P05186 |
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Gene Accession: |
BC110909 |
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Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
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Expression system: |
Escherichia coli |
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Tags: |
His tag C-Terminus, GST tag N-Terminus |
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Background: |
This gene encodes a member of the alkaline phosphatase family of proteins. There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature enzyme. This enzyme may play a role in bone mineralization. Mutations in this gene have been linked to hypophosphatasia, a disorder that is characterized by hypercalcemia and skeletal defects. |
