Name: DPM1抗原（重組蛋白）
Brand: 通蔚生物

中文名稱： DPM1抗原（重組蛋白）

英文名稱： DPM1 Antigen (Recombinant Protein)

別名： MPDS; CDGIE

儲存： 冷凍（-20℃）

相關(guān)類別：抗原

概述

Full length fusion protein

技術(shù)規(guī)格

Full name:	dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit
Synonyms:	MPDS; CDGIE
Swissprot:	O60762
Gene Accession:	BC008466
Purity:	>85%, as determined by Coomassie blue stained SDS-PAGE
Expression system:	Escherichia coli
Tags:	His tag C-Terminus, GST tag N-Terminus
Background:	Dolichol-phosphate mannose (Dol-P-Man) serves as a donor of mannosyl residues on the lumenal side of the endoplasmic reticulum (ER). Lack of Dol-P-Man results in defective surface expression of GPI-anchored proteins. Dol-P-Man is synthesized from GDP-mannose and dolichol-phosphate on the cytosolic side of the ER by the enzyme dolichyl-phosphate mannosyltransferase. Human DPM1 lacks a carboxy-terminal transmembrane domain and signal sequence and is regulated by DPM2. Mutations in this gene are associated with congenital disorder of glycosylation type Ie. Alternative splicing results in multiple transcript variants.

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