購物車
幫助
021-54845833/15800441009
技術(shù)規(guī)格
|
Background: |
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. |
|
Applications: |
IHC |
|
Name of antibody: |
IGF1R(Phospho-Tyr1346) |
|
Immunogen: |
Peptide sequence around phosphorylation site of tyrosine 1346(Q-P-Y(p)-A-H) derived from Human IGF1R . |
|
Full name: |
insulin-like growth factor 1 receptor |
|
Synonyms： |
IGFR; CD221; IGFIR; JTK13 |
|
SwissProt: |
P08069 |
|
IHC positive control: |
Human brain tissue |
|
IHC Recommend dilution: |
50-100 |
