儲 存: 冷凍(-20℃)
宿 主: Rabbit
反應種屬: Human, Rat
標 記 物: Unconjugate
技術規格
Background: |
Serine/threonine-protein kinase involved in transcription regulation, apoptosis and steroidogenic gene expression. Phosphorylates JUN and RUNX2. Seems to negatively regulate apoptosis by promoting FADD phosphorylation. Enhances androgen receptor-mediated transcription. May act as a transcriptional corepressor for NK homeodomain transcription factors. The phosphorylation of NR5A1 activates SF1 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. In osteoblasts, supports transcription activation: phosphorylates RUNX2 that synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE). |
Applications: |
ELISA, IHC |
Name of antibody: |
HIPK3 |
Immunogen: |
Synthetic peptide of human HIPK3 |
Full name: |
homeodomain interacting protein kinase 3 |
Synonyms: |
PKY; YAK1; DYRK6; FIST3 |
SwissProt: |
Q9H422 |
ELISA Recommended dilution: |
5000-10000 |
IHC positive control: |
Human thyroid cancer;Human esophagus cancer |
IHC Recommend dilution: |
25-100 |

