中文名稱：小鼠抗CASP8單克隆抗體

英文名稱： Anti-CASP8 mouse monoclonal antibody

別名： caspase 8; CAP4; MACH; MCH5; FLICE; ALPS2B; Casp-8

相關(guān)類別：一抗

儲(chǔ) 存： 冷凍（-20℃）

宿主： Mouse

抗原： CASP8

反應(yīng)種屬： Human

標(biāo) 記物： Unconjugate

克隆類型： mouse monoclonal

技術(shù)規(guī)格

Background:

This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined.

Applications:

WB

Name of antibody:

CASP8

Immunogen:

Fusion protein of human CASP8

Full name:

caspase 8

Synonyms:

CAP4; MACH; MCH5; FLICE; ALPS2B; Casp-8

SwissProt:

Q14790

WB Predicted band size:

55 kDa

WB Positive control:

Hela cell lysate

WB Recommended dilution:

500-1000

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細(xì)胞系

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細(xì)胞專用培養(yǎng)基

菌株

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形態(tài)病理檢測(cè)

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小鼠抗CASP8單克隆抗體

Background:	This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined.
Applications:	WB
Name of antibody:	CASP8
Immunogen:	Fusion protein of human CASP8
Full name:	caspase 8
Synonyms:	CAP4; MACH; MCH5; FLICE; ALPS2B; Casp-8
SwissProt:	Q14790
WB Predicted band size:	55 kDa
WB Positive control:	Hela cell lysate
WB Recommended dilution:	500-1000