Name: SRGAP3 抗原（重組蛋白）
Brand: 通蔚生物

中文名稱： SRGAP3 抗原（重組蛋白）

英文名稱： SRGAP3 Antigen (Recombinant Protein)

別名： SLIT-ROBO Rho GTPase activating protein 3; WRP; MEGAP; SRGAP2; ARHGAP14

儲存： 冷凍（-20℃）

相關類別：抗原

概述

Fusion protein corresponding to N terminal 250 amino acids of human SRGAP3

技術規格

Full name:	SLIT-ROBO Rho GTPase activating protein 3
Synonyms:	WRP; MEGAP; SRGAP2; ARHGAP14
Swissprot:	O43295
Gene Accession:	BC039300
Purity:	>85%, as determined by Coomassie blue stained SDS-PAGE
Expression system:	Escherichia coli
Tags:	His tag C-Terminus, GST tag N-Terminus
Background:	SRGAP3 is a 1099 amino acid protein containing 1 FCH domain, 1 Rho-GAP domain and 1 SH3 domain. Expressed highly in brain, and in lower levels in kidney, WRP is thought to play a role in cell migration through its interaction with Cdc42 and Rac1. Cdc42 and Rac1 are two intracellular signaling proteins that regulate the multistep cell migration process. WRP downregulates Cdc42 and Rac1 activity, thereby impairing actin and microtubule dynamics, the formation of protrusions, and total cell migration. Defects in the gene encoding WRP have been linked to severe idiopathic mental retardation. Three isoforms of WRP exist as a result of alternative splicing events.

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