購(gòu)物車(chē)
幫助
021-54845833/15800441009
中文名稱(chēng): 兔抗APOBEC3D/F多克隆抗體
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Background: |
DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. Exhibits antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single-or double-stranded RNA. May inhibit the mobility of LTR and non-LTR retrotransposons. |
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Applications: |
WB, IHC |
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Name of antibody: |
APOBEC3D/F |
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Immunogen: |
Synthesized peptide derived from internal of human APOBEC3D/F. |
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Full name: |
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D/F |
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Synonyms： |
A3D; ARP6; APOBEC3E; APOBEC3DE/A3F; KA6; ARP8; BK150C2.4.MRNA |
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SwissProt: |
Q96AK3/Q8IUX4 |
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IHC positive control: |
Human placenta tissue |
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IHC Recommend dilution: |
50-100 |
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WB Predicted band size: |
47/45 kDa |
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WB Positive control: |
MCF7 cells and COS-7cells lysates |
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WB Recommended dilution: |
500-3000 |
