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  • 兔抗PRKAR1A多克隆抗體

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    • 品牌 : 通蔚生物
    • 目錄號 : TW21937
    • 應用 : 僅供科研使用
    • 保存條件 : 低溫保存
    • 貨期 : 現貨
    • 商品庫存:80
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中文名稱:   兔抗PRKAR1A多克隆抗體


英文名稱:   Anti-PRKAR1A rabbit polyclonal antibody


別        名:   PRKAR1A; CAR; CNC; CNC1; DKFZp779L0468; MGC17251; PKR1; PPNAD1; PRKAR1; TSE1


相關類別:   一抗


儲       存:   冷凍(-20℃) 避光


宿      主:   Rabbit


抗       原:   PRKAR1A


反應種屬:   Human, Mouse, Rat


標  記  物:   Unconjugate


克隆類型:   rabbit polyclonal


技術規格

Background:

The second messenger cyclic AMP (cAMP) activates cAMP-dependent protein kinase (PKA or cAPK) in mammalian cells and controls many cellular mechanisms such as gene transcription, ion transport, and protein phosphorylation. Inactive PKA is a heterotetramer composed of a regulatory subunit (R) dimer and a catalytic subunit (C) dimer. In this inactive state, the pseudosubstrate sequences on the R subunits block the active sites on the C subunits. Three C subunit isoforms (C-α, C-β, and C-γ) and two families of regulatory subunits (RI and RII) with distinct cAMP binding properties have been identified. The two R families exist in two isoforms, α and β (RI-α, RI-β, RII-α, and RII-β). Upon binding of cAMP to the R subunits, the autoinhibitory contact is eased and active monomeric C subunits are released. PKA shares substrate specificity with Akt (PKB) and PKC, which are characterized by an arginine at position -3 relative to the phosphorylated serine or threonine residue. Substrates that present this consensus sequence and have been shown to be phosphorylated by PKA are Bad (Ser155), CREB (Ser133), and GSK-3 (GSK-3α Ser21 and GSK-3β Ser9). In addition, combined knock-down of PKA C-α and -β blocks cAMP-mediated phosphorylation of Raf (Ser43 and Ser259). Autophosphorylation and phosphorylation by PDK-1 are two known mechanisms responsible for phosphorylation of the C subunit at Thr197.

Applications:

WB

Name of antibody:

PRKAR1A

Immunogen:

Fusion protein of human PRKAR1A

Full name:

protein kinase, cAMP-dependent, regulatory, type I, alpha

Synonyms:

PRKAR1A; CAR; CNC; CNC1; DKFZp779L0468; MGC17251; PKR1; PPNAD1; PRKAR1; TSE1

SwissProt:

P10644

WB Predicted band size:

43 kDa

WB Positive control:

HeLa, CEM, A549, SW480, PC3, V251, HCTnb and heart tissue

WB Recommended dilution:

500-2000




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