中文名稱：兔抗DHCR7多克隆抗體

英文名稱： Anti-DHCR7 rabbit polyclonal antibody

別名： SLOS

相關(guān)類別：一抗

抗原： DHCR7

儲存： 冷凍（-20℃）

宿主： Rabbit

反應(yīng)種屬： Human, Mouse

標記物： Unconjugate

克隆類型： rabbit polyclonal

技術(shù)規(guī)格

Background:

This gene encodes an enzyme that removes the C(7-8) double bond in the B ring of sterols and catalyzes the conversion of 7-dehydrocholesterol to cholesterol. This gene is ubiquitously expressed and its transmembrane protein localizes to the endoplasmic reticulum membrane and nuclear outer membrane. Mutations in this gene cause Smith-Lemli-Opitz syndrome (SLOS); a syndrome that is metabolically characterized by reduced serum cholesterol levels and elevated serum 7-dehydrocholesterol levels and phenotypically characterized by mental retardation, facial dysmorphism, syndactyly of second and third toes, and holoprosencephaly in severe cases to minimal physical abnormalities and near-normal intelligence in mild cases. Alternative splicing results in multiple transcript variants that encode the same protein.

Applications:

ELISA, IHC

Name of antibody:

DHCR7

Immunogen:

Fusion protein of human DHCR7

Full name:

7-dehydrocholesterol reductase

Synonyms：

SLOS

SwissProt:

Q9UBM7

ELISA Recommended dilution:

1000-2000

IHC positive control:

Human colon cancer and human thyroid cancer

IHC Recommend dilution:

25-100

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兔抗DHCR7多克隆抗體

Background:	This gene encodes an enzyme that removes the C(7-8) double bond in the B ring of sterols and catalyzes the conversion of 7-dehydrocholesterol to cholesterol. This gene is ubiquitously expressed and its transmembrane protein localizes to the endoplasmic reticulum membrane and nuclear outer membrane. Mutations in this gene cause Smith-Lemli-Opitz syndrome (SLOS); a syndrome that is metabolically characterized by reduced serum cholesterol levels and elevated serum 7-dehydrocholesterol levels and phenotypically characterized by mental retardation, facial dysmorphism, syndactyly of second and third toes, and holoprosencephaly in severe cases to minimal physical abnormalities and near-normal intelligence in mild cases. Alternative splicing results in multiple transcript variants that encode the same protein.
Applications:	ELISA, IHC
Name of antibody:	DHCR7
Immunogen:	Fusion protein of human DHCR7
Full name:	7-dehydrocholesterol reductase
Synonyms：	SLOS
SwissProt:	Q9UBM7
ELISA Recommended dilution:	1000-2000
IHC positive control:	Human colon cancer and human thyroid cancer
IHC Recommend dilution:	25-100