Name: SETD2抗原（重組蛋白）
Brand: 通蔚生物

中文名稱(chēng)：SETD2抗原（重組蛋白）

英文名稱(chēng)： SETD2 Antigen (Recombinant Protein)

別名： HYPB; SET2; HIF-1; HIP-1; KMT3A; HBP231; HSPC069; p231HBP

儲(chǔ) 存： 冷凍（-20℃）

相關(guān)類(lèi)別： 抗原

概述：

Fusion protein corresponding to C terminal 250 amino acids of human SETD2

技術(shù)規(guī)格：

Full name:	SET domain containing 2
Synonyms:	HYPB; SET2; HIF-1; HIP-1; KMT3A; HBP231; HSPC069; p231HBP
Swissprot:	Q9BYW2
Gene Accession:	BC117162
Purity:	>85%, as determined by Coomassie blue stained SDS-PAGE
Expression system:	Escherichia coli
Tags:	His tag C-Terminus, GST tag N-Terminus
Background:	Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein belonging to a class of huntingtin interacting proteins characterized by WW motifs. This protein is a histone methyltransferase that is specific for lysine-36 of histone H3, and methylation of this residue is associated with active chromatin. This protein also contains a novel transcriptional activation domain and has been found associated with hyperphosphorylated RNA polymerase II.

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