購(gòu)物車(chē)
幫助
021-54845833/15800441009
中文名稱(chēng)： MCM3AP抗原（重組蛋白）
英文名稱(chēng)：MCM3AP Antigen (Recombinant Protein)
別 名： GANP; SAC3; MAP80
儲(chǔ) 存： 冷凍（-20℃）
相關(guān)類(lèi)別： 抗原
概 述：
|
Fusion protein corresponding to N terminal 150 amino acids of human MCM3AP |
|
Full name: |
minichromosome maintenance complex component 3 associated protein |
|
Synonyms: |
GANP; SAC3; MAP80 |
|
Swissprot: |
O60318 |
|
Gene Accession: |
BC104958 |
|
Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
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Expression system: |
Escherichia coli |
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Tags: |
His tag C-Terminus, GST tag N-Terminus |
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Background: |
The minichromosome maintenance protein 3 (MCM3) is one of the MCM proteins essential for the initiation of DNA replication. The protein encoded by this gene is a MCM3 binding protein. It was reported to have phosphorylation-dependent DNA-primase activity, which was up-regulated in antigen immunization induced germinal center. This protein was demonstrated to be an acetyltransferase that acetylates MCM3 and plays a role in DNA replication. The mutagenesis of a nuclear localization signal of MCM3 affects the binding of this protein with MCM3, suggesting that this protein may also facilitate MCM3 nuclear localization. This gene is expressed in the brain or in neuronal tissue. An allelic variant encoding amino acid Lys at 915, instead of conserved Glu, has been identified in patients with mild intellectual disability. |
