購(gòu)物車
幫助
021-54845833/15800441009
中文名稱： GCK抗原（重組蛋白）
英文名稱： GCK Antigen (Recombinant Protein)
別 名： GK; GLK; HK4; HHF3; HKIV; HXKP; LGLK; MODY2; FGQTL3
儲(chǔ) 存： 冷凍（-20℃）
相關(guān)類別： 抗原
概 述：
|
Fusion protein corresponding to a region derived from 84-290 amino acids of human GCK |
|
Full name: |
glucokinase (hexokinase 4) |
|
Synonyms: |
GK; GLK; HK4; HHF3; HKIV; HXKP; LGLK; MODY2; FGQTL3 |
|
Swissprot: |
P35557 |
|
Gene Accession: |
BC001890 |
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Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
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Expression system: |
Escherichia coli |
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Tags: |
His tag C-Terminus, GST tag N-Terminus |
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Background: |
Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. Alternative splicing of this gene results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in this gene have been associated with non-insulin dependent diabetes mellitus (NIDDM), maturity onset diabetes of the young, type 2 (MODY2) and persistent hyperinsulinemic hypoglycemia of infancy (PHHI). |
