Name: DAB2抗原（重組蛋白）
Brand: 通蔚生物

中文名稱： DAB2抗原（重組蛋白）

英文名稱： DAB2 Antigen (Recombinant Protein)

別名： DOC2; DOC-2

儲存： 冷凍（-20℃）

相關類別：抗原

概述：

Fusion protein corresponding to a region derived from 209-447 amino acids of human DAB2

技術規格：

Full name:	DAB adaptor protein 2
Synonyms:	DOC2; DOC-2
Swissprot:	P98082
Gene Accession:	BC003064
Purity:	>85%, as determined by Coomassie blue stained SDS-PAGE
Expression system:	Escherichia coli
Tags:	His tag C-Terminus, GST tag N-Terminus
Background:	This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

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